PUBLICATIONS

2019

Saha P, Sharma S, Korutla L, Datla SR, Shoja-Taheri F, Mishra R, Bigham GE, Sarkar M, Morales D, Bittle G, Gunasekaran M, Ambastha C, Arfat MY, Li D, Habertheuer A, Hu R, Platt MO, Yang P, Davis ME, Vallabhajosyula P, Kaushal S. Circulating exosomes derived from transplanted progenitor cells aid the functional recovery of ischemic myocardium. Sci Transl Med. 2019 May 22;11(493). doi: 10.1126/scitranslmed.aau1168. PubMed PMID: 31118291.

Xu C, Chen X, Sheng WB, Yang P. Trehalose restores functional autophagy suppressed by high glucose. Reprod Toxicol.2019 Apr;85:51-58. doi: 10.1016/j.reprotox.2019.02.005. Epub 2019 Feb 12. PubMed PMID: 30769031.

Zheng Y, Liu C, Li Y, Jiang H, Yang P, Tang J, Xu Y, Wang H, He Y. Loss-of-function mutations with circadian rhythm regulator Per1/Per2 lead to premature ovarian insufficiency†. Biol Reprod. 2019 Apr 1;100(4):1066-1072. doi: 10.1093/biolre/ioy245. PubMed PMID: 30452546; PubMed Central PMCID: PMC6483055.

Yang P, Xu C, Reece EA, Chen X, Zhong J, Zhan M, Stumpo DJ, Blackshear PJ, Yang P. Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy. Nat Commun. 2019 Jan 17;10(1):282. doi: 10.1038/s41467-018-08268-6. PubMed PMID: 30655546; PubMed Central PMCID: PMC6336777.

2018

Xu C, Chen X, Reece EA, Lu W, Yang P. The increased activity of a transcription factor inhibits autophagy in diabetic embryopathy. Am J Obstet Gynecol. 2019 Jan;220(1):108.e1-108.e12. doi: 10.1016/j.ajog.2018.10.001. Epub 2018 Oct 9. PubMed PMID: 30312583; PubMed Central PMCID: PMC6463484.

Chen X, Ai X, Wu C, Wang H, Zeng G, Yang P, Liu G. A novel human IL-2 mutein with minimal systemic toxicity exerts greater antitumor efficacy than wild-type IL-2. Cell Death Dis. 2018 Sep 24;9(10):989. doi: 10.1038/s41419-018-1047-2. PubMed PMID: 30250191; PubMed Central PMCID: PMC6155133.

Dong D, Zielke HR, Yeh D, Yang P. Cellular stress and apoptosis contribute to the pathogenesis of autism spectrum disorder. Autism Res. 2018 Jul;11(7):1076-1090. doi: 10.1002/aur.1966. Epub 2018 May 15. PubMed PMID: 29761862; PubMed Central PMCID: PMC6107407.

Chung HK, Wang SR, Xiao L, Rathor N, Turner DJ, Yang P, Gorospe M, Rao JN, Wang JY. α4 Coordinates Small Intestinal Epithelium Homeostasis by Regulating Stability of HuR. Mol Cell Biol. 2018 Jun 1;38(11). doi: 10.1128/MCB.00631-17. Print 2018 Jun 1. PubMed PMID: 29555726; PubMed Central PMCID: PMC5954190.

Chen X, Shen WB, Yang P, Dong D, Sun W, Yang P. High Glucose Inhibits Neural Stem Cell Differentiation Through Oxidative Stress and Endoplasmic Reticulum Stress. Stem Cells Dev. 2018 Jun 1;27(11):745-755. doi: 10.1089/scd.2017.0203. PubMed PMID: 29695191; PubMed Central PMCID: PMC5985912.

Ambastha C, Bittle GJ, Morales D, Parchment N, Saha P, Mishra R, Sharma S, Vasilenko A, Gunasekaran M, Al-Suqi MT, Li D, Yang P, Kaushal S. Regenerative medicine therapy for single ventricle congenital heart disease. Transl Pediatr. 2018 Apr;7(2):176-187. doi: 10.21037/tp.2018.04.01. Review. PubMed PMID: 29770299; PubMed Central PMCID: PMC5938254.

White K, Yang P, Li L, Farshori A, Medina AE, Zielke HR. Effect of Postmortem Interval and Years in Storage on RNA Quality of Tissue at a Repository of the NIH NeuroBioBank. Biopreserv Biobank. 2018 Apr;16(2):148-157. doi: 10.1089/bio.2017.0099. Epub 2018 Mar 2. PubMed PMID: 29498539; PubMed Central PMCID: PMC5906728.

Zhao Y, Dong D, Reece EA, Wang AR, Yang P. Oxidative stress-induced miR-27a targets the redox gene nuclear factor erythroid 2-related factor 2 in diabetic embryopathy. Am J Obstet Gynecol. 2018 Jan;218(1):136.e1-136.e10. doi: 10.1016/j.ajog.2017.10.040. Epub 2017 Nov 1. PubMed PMID: 29100869; PubMed Central PMCID: PMC5785788.

Zhong J, Wang S, Shen WB, Kaushal S, Yang P. The current status and future of cardiac stem/progenitor cell therapy for congenital heart defects from diabetic pregnancy. Pediatr Res. 2018 Jan;83(1-2):275-282. doi: 10.1038/pr.2017.259. Epub 2017 Nov 15. Review. PubMed PMID: 29016556; PubMed Central PMCID: PMC5876137.

2017

Chen X, Zhong J, Dong D, Liu G, Yang P. Endoplasmic Reticulum Stress-Induced CHOP Inhibits PGC-1α and Causes Mitochondrial Dysfunction in Diabetic Embryopathy. Toxicol Sci. 2017 Aug 1;158(2):275-285. doi: 10.1093/toxsci/kfx096. PubMed PMID: 28482072; PubMed Central PMCID: PMC5837255.

Lin X, Yang P, Reece EA, Yang P. Pregestational type 2 diabetes mellitus induces cardiac hypertrophy in the murine embryo through cardiac remodeling and fibrosis. Am J Obstet Gynecol. 2017 Aug;217(2):216.e1-216.e13. doi: 10.1016/j.ajog.2017.04.008. Epub 2017 Apr 13. PubMed PMID: 28412087; PubMed Central PMCID: PMC5787338.

Wang F, Xu C, Reece EA, Li X, Wu Y, Harman C, Yu J, Dong D, Wang C, Yang P, Zhong J, Yang P. Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy. Nat Commun. 2017 May 5;8:15182. doi: 10.1038/ncomms15182. PubMed PMID: 28474670; PubMed Central PMCID: PMC5424165.

Zhong Y, Wang J, Henderson MJ, Yang P, Hagen BM, Siddique T, Vogel BE, Deng HX, Fang S. Nuclear export of misfolded SOD1 mediated by a normally buried NES-like sequence reduces proteotoxicity in the nucleus. Elife. 2017 May 2;6. doi: 10.7554/eLife.23759. PubMed PMID: 28463106; PubMed Central PMCID: PMC5449186.

Sharma S, Mishra R, Bigham GE, Wehman B, Khan MM, Xu H, Saha P, Goo YA, Datla SR, Chen L, Tulapurkar ME, Taylor BS, Yang P, Karathanasis S, Goodlett DR, Kaushal S. A Deep Proteome Analysis Identifies the Complete Secretome as the Functional Unit of Human Cardiac Progenitor Cells. Circ Res. 2017 Mar 3;120(5):816-834. doi: 10.1161/CIRCRESAHA.116.309782. Epub 2016 Dec 1. PubMed PMID: 27908912; PubMed Central PMCID: PMC5834230.

Gabbay-Benziv R, Reece EA, Wang F, Bar-Shir A, Harman C, Turan OM, Yang P, Turan S. A step-wise approach for analysis of the mouse embryonic heart using 17.6Tesla MRI. Magn Reson Imaging. 2017 Jan;35:46-53. doi: 10.1016/j.mri.2016.08.008. Epub 2016 Aug 26. PubMed PMID: 27569369; PubMed Central PMCID: PMC5805481.

2016

Yang P, Chen X, Kaushal S, Reece EA, Yang P. High glucose suppresses embryonic stem cell differentiation into cardiomyocytes : High glucose inhibits ES cell cardiogenesis. Stem Cell Res Ther. 2016 Dec 9;7(1):187. doi: 10.1186/s13287-016-0446-5. PubMed PMID: 27938398; PubMed Central PMCID: PMC5148851.

Wang H, Hong CE, Lewis JP, Zhu Y, Wang X, Chu X, Backman J, Hu Z, Yang P, Still CD, Gerhard GS, Fu M. Effect of Two Lipoprotein (a)-Associated Genetic Variants on Plasminogen Levels and Fibrinolysis. G3 (Bethesda). 2016 Nov 8;6(11):3525-3532. doi: 10.1534/g3.116.034702. PubMed PMID: 27605514; PubMed Central PMCID: PMC5100851.

Dong D, Zhang Y, Reece EA, Wang L, Harman CR, Yang P. microRNA expression profiling and functional annotation analysis of their targets modulated by oxidative stress during embryonic heart development in diabetic mice. Reprod Toxicol. 2016 Oct;65:365-374. doi: 10.1016/j.reprotox.2016.09.007. Epub 2016 Sep 11. PubMed PMID: 27629361; PubMed Central PMCID: PMC5288404.

Wu Y, Reece EA, Zhong J, Dong D, Shen WB, Harman CR, Yang P. Type 2 diabetes mellitus induces congenital heart defects in murine embryos by increasing oxidative stress, endoplasmic reticulum stress, and apoptosis. Am J Obstet Gynecol. 2016 Sep;215(3):366.e1-366.e10. doi: 10.1016/j.ajog.2016.03.036. Epub 2016 Mar 31. PubMed PMID: 27038779; PubMed Central PMCID: PMC5260663.

Zhong J, Xu C, Reece EA, Yang P. The green tea polyphenol EGCG alleviates maternal diabetes-induced neural tube defects by inhibiting DNA hypermethylation. Am J Obstet Gynecol. 2016 Sep;215(3):368.e1-368.e10. doi: 10.1016/j.ajog.2016.03.009. Epub 2016 Mar 12. PubMed PMID: 26979632; PubMed Central PMCID: PMC5270539.

Dong D, Reece EA, Yang P. The Nrf2 Activator Vinylsulfone Reduces High Glucose-Induced Neural Tube Defects by Suppressing Cellular Stress and Apoptosis. Reprod Sci. 2016 Aug;23(8):993-1000. doi: 10.1177/1933719115625846. Epub 2016 Jan 21. PubMed PMID: 26802109; PubMed Central PMCID: PMC5933102.

Hua G, He C, Lv X, Fan L, Wang C, Remmenga SW, Rodabaugh KJ, Yang L, Lele SM, Yang P, Karpf AR, Davis JS, Wang C. The four and a half LIM domains 2 (FHL2) regulates ovarian granulosa cell tumor progression via controlling AKT1 transcription. Cell Death Dis. 2016 Jul 14;7:e2297. doi: 10.1038/cddis.2016.207. PubMed PMID: 27415427; PubMed Central PMCID: PMC4973349.

Banerjee A, Ahmed H, Yang P, Czinn SJ, Blanchard TG. Endoplasmic reticulum stress and IRE-1 signaling cause apoptosis in colon cancer cells in response to andrographolide treatment. Oncotarget. 2016 Jul 5;7(27):41432-41444. doi: 10.18632/oncotarget.9180. PubMed PMID: 27166181; PubMed Central PMCID: PMC5173070.

Zhong J, Xu C, Gabbay-Benziv R, Lin X, Yang P. Superoxide dismutase 2 overexpression alleviates maternal diabetes-induced neural tube defects, restores mitochondrial function and suppresses cellular stress in diabetic embryopathy.Free Radic Biol Med. 2016 Jul;96:234-44. doi: 10.1016/j.freeradbiomed.2016.04.030. Epub 2016 Apr 27. PubMed PMID: 27130031; PubMed Central PMCID: PMC4912469.

Yu J, Wu Y, Yang P. High glucose-induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects. J Neurochem. 2016 May;137(3):371-83. doi: 10.1111/jnc.13587. Epub 2016 Mar 17. PubMed PMID: 26896748; PubMed Central PMCID: PMC4837015.

Hua G, Lv X, He C, Remmenga SW, Rodabough KJ, Dong J, Yang L, Lele SM, Yang P, Zhou J, Karst A, Drapkin RI, Davis JS, Wang C. YAP induces high-grade serous carcinoma in fallopian tube secretory epithelial cells. Oncogene. 2016 Apr 28;35(17):2247-65. doi: 10.1038/onc.2015.288. Epub 2015 Sep 14. PubMed PMID: 26364602; PubMed Central PMCID: PMC4791205.

Yang P, Shen WB, Reece EA, Chen X, Yang P. High glucose suppresses embryonic stem cell differentiation into neural lineage cells. Biochem Biophys Res Commun. 2016 Apr 1;472(2):306-12. doi: 10.1016/j.bbrc.2016.02.117. Epub 2016 Mar 3. PubMed PMID: 26940741; PubMed Central PMCID: PMC5264524.

Dong D, Fu N, Yang P. MiR-17 Downregulation by High Glucose Stabilizes Thioredoxin-Interacting Protein and Removes Thioredoxin Inhibition on ASK1 Leading to Apoptosis. Toxicol Sci. 2016 Mar;150(1):84-96. doi: 10.1093/toxsci/kfv313. Epub 2015 Dec 10. PubMed PMID: 26660634; PubMed Central PMCID: PMC4830238.

Dong D, Reece EA, Lin X, Wu Y, AriasVillela N, Yang P. New development of the yolk sac theory in diabetic embryopathy: molecular mechanism and link to structural birth defects. Am J Obstet Gynecol. 2016 Feb;214(2):192-202. doi: 10.1016/j.ajog.2015.09.082. Epub 2015 Sep 30. Review. PubMed PMID: 26432466; PubMed Central PMCID: PMC4744545.

Klionsky DJ, Abdelmohsen K, Abe A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356. PubMed PMID: 26799652; PubMed Central PMCID: PMC4835977.

Gu H, Yu J, Dong D, Zhou Q, Wang JY, Fang S, Yang P. High Glucose-Repressed CITED2 Expression Through miR-200b Triggers the Unfolded Protein Response and Endoplasmic Reticulum Stress. Diabetes. 2016 Jan;65(1):149-63. doi: 10.2337/db15-0108. Epub 2015 Oct 8. PubMed PMID: 26450995; PubMed Central PMCID: PMC4686950.

Gernapudi R, Wolfson B, Zhang Y, Yao Y, Yang P, Asahara H, Zhou Q. MicroRNA 140 Promotes Expression of Long Noncoding RNA NEAT1 in Adipogenesis. Mol Cell Biol. 2016 Jan 1;36(1):30-8. doi: 10.1128/MCB.00702-15. Print 2016 Jan 1. PubMed PMID: 26459763; PubMed Central PMCID: PMC4702608.

2015

Wang F, Weng H, Quon MJ, Yu J, Wang JY, Hueber AO, Yang P. Dominant negative FADD dissipates the proapoptotic signalosome of the unfolded protein response in diabetic embryopathy. Am J Physiol Endocrinol Metab. 2015 Nov 15;309(10):E861-73. doi: 10.1152/ajpendo.00215.2015. Epub 2015 Sep 29. PubMed PMID: 26419589; PubMed Central PMCID: PMC4652069.

Dong D, Yu J, Wu Y, Fu N, Villela NA, Yang P. Maternal diabetes triggers DNA damage and DNA damage response in neurulation stage embryos through oxidative stress. Biochem Biophys Res Commun. 2015 Nov 13;467(2):407-12. doi: 10.1016/j.bbrc.2015.09.137. Epub 2015 Sep 30. PubMed PMID: 26427872; PubMed Central PMCID: PMC4618162.

Zhong J, Reece EA, Yang P. Punicalagin exerts protective effect against high glucose-induced cellular stress and neural tube defects. Biochem Biophys Res Commun. 2015 Nov 13;467(2):179-84. doi: 10.1016/j.bbrc.2015.10.024. Epub 2015 Oct 13. PubMed PMID: 26453010; PubMed Central PMCID: PMC4621080.

He C, Mao D, Hua G, Lv X, Chen X, Angeletti PC, Dong J, Remmenga SW, Rodabaugh KJ, Zhou J, Lambert PF, Yang P, Davis JS, Wang C. The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression. EMBO Mol Med. 2015 Nov;7(11):1426-49. doi: 10.15252/emmm.201404976. PubMed PMID: 26417066; PubMed Central PMCID: PMC4644376.

Chung HK, Chen Y, Rao JN, Liu L, Xiao L, Turner DJ, Yang P, Gorospe M, Wang JY. Transgenic Expression of miR-222 Disrupts Intestinal Epithelial Regeneration by Targeting Multiple Genes Including Frizzled-7. Mol Med. 2015 Nov;21(1):676-687. doi: 10.2119/molmed.2015.00147. Epub 2015 Aug 3. PubMed PMID: 26252186; PubMed Central PMCID: PMC4749484.

Wang F, Fisher SA, Zhong J, Wu Y, Yang P. Superoxide Dismutase 1 In Vivo Ameliorates Maternal Diabetes Mellitus-Induced Apoptosis and Heart Defects Through Restoration of Impaired Wnt Signaling. Circ Cardiovasc Genet. 2015 Oct;8(5):665-76. doi: 10.1161/CIRCGENETICS.115.001138. Epub 2015 Jul 31. PubMed PMID: 26232087; PubMed Central PMCID: PMC4618088.

Wang F, Wu Y, Quon MJ, Li X, Yang P. ASK1 mediates the teratogenicity of diabetes in the developing heart by inducing ER stress and inhibiting critical factors essential for cardiac development. Am J Physiol Endocrinol Metab. 2015 Sep 1;309(5):E487-99. doi: 10.1152/ajpendo.00121.2015. Epub 2015 Jul 14. PubMed PMID: 26173459; PubMed Central PMCID: PMC4556884.

Wang F, Reece EA, Yang P. Advances in revealing the molecular targets downstream of oxidative stress-induced proapoptotic kinase signaling in diabetic embryopathy. Am J Obstet Gynecol. 2015 Aug;213(2):125-34. doi: 10.1016/j.ajog.2015.01.016. Epub 2015 Jan 13. Review. PubMed PMID: 25595581; PubMed Central PMCID: PMC4500754.

Wu Y, Wang F, Fu M, Wang C, Quon MJ, Yang P. Cellular Stress, Excessive Apoptosis, and the Effect of Metformin in a Mouse Model of Type 2 Diabetic Embryopathy. Diabetes. 2015 Jul;64(7):2526-36. doi: 10.2337/db14-1683. Epub 2015 Feb 26. PubMed PMID: 25720389; PubMed Central PMCID: PMC4477360.

Wu Y, Wang F, Reece EA, Yang P. Curcumin ameliorates high glucose-induced neural tube defects by suppressing cellular stress and apoptosis. Am J Obstet Gynecol. 2015 Jun;212(6):802.e1-8. doi: 10.1016/j.ajog.2015.01.017. Epub 2015 Jan 13. PubMed PMID: 25595578; PubMed Central PMCID: PMC4457597

Peixin Yang’s Previous Work

Yang P, Reece EA, Wang F, Gabbay-Benziv R. Decoding the oxidative stress hypothesis in diabetic embryopathy through proapoptotic kinase signaling. Am J Obstet Gynecol. 2015 May;212(5):569-79. doi: 10.1016/j.ajog.2014.11.036. Epub 2014 Nov 27. Review. PubMed PMID: 25434839; PubMed Central PMCID: PMC4417047.

Wang F, Reece EA, Yang P. Oxidative stress is responsible for maternal diabetes-impaired transforming growth factor beta signaling in the developing mouse heart. Am J Obstet Gynecol. 2015 May;212(5):650.e1-11. doi: 10.1016/j.ajog.2015.01.014. Epub 2015 Jan 13. PubMed PMID: 25595579; PubMed Central PMCID: PMC4417061.

Gabbay-Benziv R, Reece EA, Wang F, Yang P. Birth defects in pregestational diabetes: Defect range, glycemic threshold and pathogenesis. World J Diabetes. 2015 Apr 15;6(3):481-8. doi: 10.4239/wjd.v6.i3.481. Review. PubMed PMID: 25897357; PubMed Central PMCID: PMC4398903.

Gernapudi R, Yao Y, Zhang Y, Wolfson B, Roy S, Duru N, Eades G, Yang P, Zhou Q. Targeting exosomes from preadipocytes inhibits preadipocyte to cancer stem cell signaling in early-stage breast cancer. Breast Cancer Res Treat. 2015 Apr;150(3):685-95. doi: 10.1007/s10549-015-3326-2. Epub 2015 Mar 18. PubMed PMID: 25783182; PubMed Central PMCID: PMC4385483.

Zhong Y, Shen H, Wang Y, Yang Y, Yang P, Fang S. Identification of ERAD components essential for dislocation of the null Hong Kong variant of α-1-antitrypsin (NHK). Biochem Biophys Res Commun. 2015 Mar 6;458(2):424-8. doi: 10.1016/j.bbrc.2015.01.133. Epub 2015 Feb 7. PubMed PMID: 25660456.

Wang F, Wu Y, Gu H, Reece EA, Fang S, Gabbay-Benziv R, Aberdeen G, Yang P. Ask1 gene deletion blocks maternal diabetes-induced endoplasmic reticulum stress in the developing embryo by disrupting the unfolded protein response signalosome. Diabetes. 2015 Mar;64(3):973-88. doi: 10.2337/db14-0409. Epub 2014 Sep 23. PubMed PMID: 25249581; PubMed Central PMCID: PMC4338585.

Gu H, Yu J, Dong D, Zhou Q, Wang JY, Yang P. The miR-322-TRAF3 circuit mediates the pro-apoptotic effect of high glucose on neural stem cells. Toxicol Sci. 2015 Mar;144(1):186-96. doi: 10.1093/toxsci/kfu271. Epub 2014 Dec 16. PubMed PMID: 25516495; PubMed Central PMCID: PMC4349142.

Keske MA, Ng HL, Premilovac D, Rattigan S, Kim JA, Munir K, Yang P, Quon MJ. Vascular and metabolic actions of the green tea polyphenol epigallocatechin gallate. Curr Med Chem. 2015;22(1):59-69. Review. PubMed PMID: 25312214; PubMed Central PMCID: PMC4909506.

Yang P, Kenchegowda D, Fisher SA. Cardiac myocyte proliferation: not as simple as counting sheep. J Mol Cell Cardiol.2014 Sep;74:125-6. doi: 10.1016/j.yjmcc.2014.05.007. Epub 2014 May 17. PubMed PMID: 24839912.

Chung HK, Rao JN, Zou T, Liu L, Xiao L, Gu H, Turner DJ, Yang P, Wang JY. Jnk2 deletion disrupts intestinal mucosal homeostasis and maturation by differentially modulating RNA-binding proteins HuR and CUGBP1. Am J Physiol Cell Physiol. 2014 Jun 15;306(12):C1167-75. doi: 10.1152/ajpcell.00093.2014. Epub 2014 Apr 16. PubMed PMID: 24740539; PubMed Central PMCID: PMC4060001.

Wang F, Reece EA, Yang P. Superoxide dismutase 1 overexpression in mice abolishes maternal diabetes-induced endoplasmic reticulum stress in diabetic embryopathy. Am J Obstet Gynecol. 2013 Oct;209(4):345.e1-7. doi: 10.1016/j.ajog.2013.06.037. Epub 2013 Jun 20. PubMed PMID: 23791840; PubMed Central PMCID: PMC3786037.

Xu C, Li X, Wang F, Weng H, Yang P. Trehalose prevents neural tube defects by correcting maternal diabetes-suppressed autophagy and neurogenesis. Am J Physiol Endocrinol Metab. 2013 Sep 1;305(5):E667-78. doi: 10.1152/ajpendo.00185.2013. Epub 2013 Jul 23. PubMed PMID: 23880312; PubMed Central PMCID: PMC3761168.

Yang P, Li X, Xu C, Eckert RL, Reece EA, Zielke HR, Wang F. Maternal hyperglycemia activates an ASK1-FoxO3a-caspase 8 pathway that leads to embryonic neural tube defects. Sci Signal. 2013 Aug 27;6(290):ra74. doi: 10.1126/scisignal.2004020. PubMed PMID: 23982205; PubMed Central PMCID: PMC4768865.

Li X, Xu C, Yang P. c-Jun NH2-terminal kinase 1/2 and endoplasmic reticulum stress as interdependent and reciprocal causation in diabetic embryopathy. Diabetes. 2013 Feb;62(2):599-608. doi: 10.2337/db12-0026. Epub 2012 Sep 6. PubMed PMID: 22961085; PubMed Central PMCID: PMC3554374.

Li X, Weng H, Xu C, Reece EA, Yang P. Oxidative stress-induced JNK1/2 activation triggers proapoptotic signaling and apoptosis that leads to diabetic embryopathy. Diabetes. 2012 Aug;61(8):2084-92. doi: 10.2337/db11-1624. Epub 2012 Jun 11. PubMed PMID: 22688338; PubMed Central PMCID: PMC3402327.

Weng H, Li X, Reece EA, Yang P. SOD1 suppresses maternal hyperglycemia-increased iNOS expression and consequent nitrosative stress in diabetic embryopathy. Am J Obstet Gynecol. 2012 May;206(5):448.e1-7. doi: 10.1016/j.ajog.2012.02.011. Epub 2012 Feb 22. PubMed PMID: 22425406; PubMed Central PMCID: PMC3340508.

Li X, Weng H, Reece EA, Yang P. SOD1 overexpression in vivo blocks hyperglycemia-induced specific PKC isoforms: substrate activation and consequent lipid peroxidation in diabetic embryopathy. Am J Obstet Gynecol. 2011 Jul;205(1):84.e1-6. doi: 10.1016/j.ajog.2011.02.071. Epub 2011 Mar 5. PubMed PMID: 21529760; PubMed Central PMCID: PMC3160525.

Yang P, Reece EA. Role of HIF-1α in maternal hyperglycemia-induced embryonic vasculopathy. Am J Obstet Gynecol.2011 Apr;204(4):332.e1-7. doi: 10.1016/j.ajog.2011.01.012. Epub 2011 Feb 23. PubMed PMID: 21345401; PubMed Central PMCID: PMC3198784.

Yang P, Cao Y, Li H. Hyperglycemia induces inducible nitric oxide synthase gene expression and consequent nitrosative stress via c-Jun N-terminal kinase activation. Am J Obstet Gynecol. 2010 Aug;203(2):185.e5-11. doi: 10.1016/j.ajog.2010.05.003. Epub 2010 Jun 11. PubMed PMID: 20541731; PubMed Central PMCID: PMC2910834.

Yang P, Li H. Epigallocatechin-3-gallate ameliorates hyperglycemia-induced embryonic vasculopathy and malformation by inhibition of Foxo3a activation. Am J Obstet Gynecol. 2010 Jul;203(1):75.e1-6. doi: 10.1016/j.ajog.2010.02.008. Epub 2010 Apr 24. PubMed PMID: 20417490; PubMed Central PMCID: PMC2900479.

Zhao Z, Yang P, Eckert RL, Reece EA. Caspase-8: a key role in the pathogenesis of diabetic embryopathy. Birth Defects Res B Dev Reprod Toxicol. 2009 Feb;86(1):72-7. doi: 10.1002/bdrb.20185. PubMed PMID: 19194987; PubMed Central PMCID: PMC2838243.

Yang P, Zhao Z, Reece EA. Blockade of c-Jun N-terminal kinase activation abrogates hyperglycemia-induced yolk sac vasculopathy in vitro. Am J Obstet Gynecol. 2008 Mar;198(3):321.e1-7. doi: 10.1016/j.ajog.2007.09.010. Epub 2008 Feb 21. PubMed PMID: 18177823.

Yang P, Zhao Z, Reece EA. Activation of oxidative stress signaling that is implicated in apoptosis with a mouse model of diabetic embryopathy. Am J Obstet Gynecol. 2008 Jan;198(1):130.e1-7. doi: 10.1016/j.ajog.2007.06.070. PubMed PMID: 18166327.

Yang P, Zhao Z, Reece EA. Involvement of c-Jun N-terminal kinases activation in diabetic embryopathy. Biochem Biophys Res Commun. 2007 Jun 8;357(3):749-54. doi: 10.1016/j.bbrc.2007.04.023. Epub 2007 Apr 13. PubMed PMID: 17449011.

Yang P, Roy SK. Transforming growth factor B1 stimulated DNA synthesis in the granulosa cells of preantral follicles: negative interaction with epidermal growth factor. Biol Reprod. 2006 Jul;75(1):140-8. doi: 10.1095/biolreprod.105.050294. Epub 2006 Mar 8. PubMed PMID: 16525033; PubMed Central PMCID: PMC1482803.

Yang P, Roy SK. A novel mechanism of FSH regulation of DNA synthesis in the granulosa cells of hamster preantral follicles: involvement of a protein kinase C-mediated MAP kinase 3/1 self-activation loop. Biol Reprod. 2006 Jul;75(1):149-57. doi: 10.1095/biolreprod.105.050153. Epub 2006 Mar 8. PubMed PMID: 16525034; PubMed Central PMCID: PMC1482802.

Yang P, Medan MS, Arai KY, Jin W, Watanabe G, Taya K. Secretion of inhibin and testicular expression of inhibin subunits in male duck embryos and newly hatched ducks. Endocrine. 2005 Nov;28(2):171-9. doi: 10.1385/ENDO:28:2:171. PubMed PMID: 16388090.

Yang P, Medan M, Arai K, Jin W, Watanabe G, Taya K. Ontogeny of testicular inhibin and activin in ducks: An immunocytochemical analysis. Animal science journal = Nihon chikusan Gakkaihō. 2005 September; 76(5):427-434. doi: 10.1111/j.1740-0929.2005.00286.x.

Yang P, Medan MS, Watanabe G, Taya K. Developmental changes of plasma inhibin, gonadotropins, steroid hormones, and thyroid hormones in male and female Shao ducks. Gen Comp Endocrinol. 2005 Sep 1;143(2):161-7. doi: 10.1016/j.ygcen.2005.03.001. Epub 2005 Apr 8. PubMed PMID: 16061074.

Yang P, Medan MS, Arai KY, Watanabe G, Taya K. Plasma concentrations of immunoreactive (ir)-inhibin, gonadotropins and steroid hormones during the ovulatory cycle of the duck. J Reprod Dev. 2005 Jun;51(3):353-8. doi: 10.1262/jrd.16093. Epub 2005 Mar 11. PubMed PMID: 15764847.

Yang P, Wang J, Shen Y, Roy SK. Developmental expression of estrogen receptor (ER) alpha and ERbeta in the hamster ovary: regulation by follicle-stimulating hormone. Endocrinology. 2004 Dec;145(12):5757-66. doi: 10.1210/en.2004-0779. Epub 2004 Sep 2. PubMed PMID: 15345677.

Yang P, Roy SK. Follicle stimulating hormone-induced DNA synthesis in the granulosa cells of hamster preantral follicles involves activation of cyclin-dependent kinase-4 rather than cyclin d2 synthesis. Biol Reprod. 2004 Feb;70(2):509-17. doi: 10.1095/biolreprod.103.023457. Epub 2003 Oct 15. PubMed PMID: 14561638.

Roy SK, Wang J, Yang P. Dexamethasone inhibits transforming growth factor-beta receptor (Tbeta R) messenger RNA expression in hamster preantral follicles: possible association with NF-YA. Biol Reprod. 2003 Jun;68(6):2180-8. doi: 10.1095/biolreprod.102.013011. Epub 2003 Jan 22. PubMed PMID: 12606399.

Yang P, Kriatchko A, Roy SK. Expression of ER-alpha and ER-beta in the hamster ovary: differential regulation by gonadotropins and ovarian steroid hormones. Endocrinology. 2002 Jun;143(6):2385-98. doi: 10.1210/endo.143.6.8858. PubMed PMID: 12021204.

Yang P, Roy SK. Epidermal growth factor modulates transforming growth factor receptor messenger RNA and protein levels in hamster preantral follicles in vitro. Biol Reprod. 2001 Sep;65(3):847-54. doi: 10.1095/biolreprod65.3.847. PubMed PMID: 11514350.

Fu Y, Niu D, Ruan H, Yu XP, Chen G, He GQ, Yang PX. [cDNA cloning and mRNA expression pattern in follicles of the mature inhibin alpha subunit from Xianju chicken]. Yi Chuan Xue Bao. 2001 Aug;28(8):707-15. PubMed PMID: 11554344.

Yang PX, Arai KY, Jin WZ, Watanabe G, Groome NP, Taya K. Preovulatory follicles in the ovary as the source of circulating inhibin in the duck. Gen Comp Endocrinol. 2001 Feb;121(2):156-62. doi: 10.1006/gcen.2000.7577. PubMed PMID: 11178881.

Fu Y, Niu D, Ruan H, Yu XP, Chen G, He GQ, Yang PX. [Expression of inhibin alpha and inhibin/activin beta A subunits in the developing follicles of the duck]. Yi Chuan Xue Bao. 2001;28(6):502-9. PubMed PMID: 11431982.

Yang P, Arai K, Jin W, Watanabe G, Grrome N, Taya K. Changes in inhibin secretion during development of the female duck embryo. Zoological science. 2001; 18:1107-1112. doi: 10.2108/zsj.18.1107.

Fu Y, Niu D, Ruan H, Yu XP, Chen G, He GQ, Yang PX. [Expression pattern of mRNA for follistatin and inhibin/activin beta B-subunit during follicular and testicular development in duck]. Yi Chuan Xue Bao. 2001;28(9):808-15. PubMed PMID: 11582738.

Yang P, Cheng Z, Watanabe G, Taya K. Effects of third ventricle injection of norepinephrine analogue on LH secretion of the non-laying SIJI goose. Endocr J. 2000 Feb;47(1):7-12. PubMed PMID: 10811287.

Shi F, Ozawa M, Komura H, Yang P, Trewin AL, Hutz RJ, Watanabe G, Taya K. Secretion of ovarian inhibin and its physiologic roles in the regulation of follicle-stimulating hormone secretion during the estrous cycle of the female guinea pig. Biol Reprod. 1999 Jan;60(1):78-84. doi: 10.1095/biolreprod60.1.78. PubMed PMID: 9858489.

Link to all of Peixin Yang’s Publications: https://www.ncbi.nlm.nih.gov/sites/myncbi/1BA0Vix5gqKAE/bibliography/47370305/public/?sort=date&direction=ascending